![]() ![]() ![]() Our results favour the two-step selection model over the sequential model. With the aim to clarify which one of these models is most likely to reflect the actual biological process, we simulated the two educational schemes by mathematical modelling, and fitted the results to Ly49 expression patterns, which were analyzed in mice expressing single MHC class I molecules. The sequential model, on the other hand, proposes that each NK cell sequentially expresses Ly49 receptors until an interaction of sufficient magnitude with self-class I MHC is reached for the NK cell to mature. The two-step selection model proposes a stochastic Ly49 receptor expression followed by selection for NK cells expressing appropriate receptor combinations. Two models have been put forward to explain this impact. ![]() As a result, mice with different MHC class I expression display different frequency distributions of Ly49 receptor combinations on NK cells. During murine NK cell development, host MHC class I molecules impose an “educating impact” on the NK cell pool. Murine natural killer (NK) cells express inhibitory Ly49 receptors for MHC class I molecules, which allows for “missing self” recognition of cells that downregulate MHC class I expression.
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